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C7017 Sigma-Aldrich

Choline chloride

≥99%

Synonym: (2-Hydroxyethyl)trimethylammonium chloride

  • CAS Number 67-48-1

  • Linear Formula (CH3)3N(Cl)CH2CH2OH

  • Molecular Weight 139.62

  •  Beilstein/REAXYS Number 3563126

  •  EC Number 200-655-4

  •  MDL number MFCD00011721

  •  PubChem Substance ID 57654039

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Properties

Related Categories Ammonium Salts, Cell Biology, Chemical Synthesis, Glycerolipid Metabolism, Lipid,
biological source   synthetic
InChI Key   SGMZJAMFUVOLNK-UHFFFAOYSA-M
assay   ≥99%
form   powder
color   white
mp   302-305 °C (dec.) (lit.)

Description

General description

Choline is a constituent of sphingomyelin and lecithin. It is a precursor of acetylcholine. Choline plays a vital role in methyl group metabolism, carcinogenesis and lipid transport. Choline deficiency is associated with fatty liver. It maintains cell structural integrity and cell signalling. Choline is implicated in the synthesis of phospholipids. It acts as a potent biomarker for ischemic heart disease.

Application

Choline chloride has been used:
• in choline release assay
• as an endogenous agonist of sigma-1 receptors (Sig-1Rs)
• as a standard to analyse interrelationships between methionine and choline metabolism

Packaging

10 mg in autosample vial

5, 25, 100 g in glass bottle

Biochem/physiol Actions

Choline is an essential nutrient, commonly grouped with the B complex vitamins, that plays key roles in many biological processes.

The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes .

Substrates

Choline acetyltransferase substrate

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
KH2975000

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles
Peer-Reviewed Papers
15

References

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