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  • C7159 - Monoclonal Anti-Cytokeratin 4.62 antibody produced in mouse

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C7159 Sigma-Aldrich

Monoclonal Anti-Cytokeratin 4.62 antibody produced in mouse

clone K4.62, ascites fluid

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cell and Organelle Proteins, Antibodies to Cytokeratins,
conjugate   unconjugated
clone   K4.62, monoclonal
biological source   mouse
application(s)   indirect immunofluorescence: 1:20 using frozen human tissue sections
species reactivity   human
shipped in   dry ice
storage temp.   −20°C
antibody form   ascites fluid
isotype   IgG1
antibody product type   primary antibodies
contains   15 mM sodium azide
UniProt accession no.   P08727
Gene Information   human ... KRT19(3880)

Description

Specificity

Reacts with cytokeratin polypeptide 19. The antibody labels the basal layer of non-keratinizing epithelium, metaplastic epithelium of the cervix, simple epithelium, transitional epithelium, squamous cell carcinomas and adenocarcinomas expressing cytokeratin 19.

Immunogen

cytoskeletal proteins from the cultured human breast carcinoma cell line MCF-7

Application

Monoclonal Anti-Cytokeratin 4.62 antibody produced in mouse is suitable for indirect immunofluorescence at a dilution of 1:20 using frozen human tissue sections.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Cytokeratins are proteins of keratin-containing intermediate filaments that provide mechanical support and other additional functions in epithelial cells. It is found in the intracytoplasmic cytoskeleton of epithelial tissue. Epithelial tissue expresses cytokeratin subunits in a specific and stable pattern. Cytokeratins along with vimentin are involved in cell proliferation, migration and differentiation of preodontoblasts and preameloblasts. The intermediate-sized filaments are abundant in human endothelial cells and are mostly of vimentin type.

Safety & Documentation

Safety Information

WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Peer-Reviewed Papers
15

References

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