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C7374 Sigma-Aldrich

CK-636

≥98% (HPLC)

Synonym: CK-0944636; N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide

  • CAS Number 442632-72-6

  • Empirical Formula (Hill Notation) C16H16N2OS

  • Molecular Weight 284.38

  •  MDL number MFCD03036245

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology
assay   ≥98% (HPLC)
form   powder
color   peach to light pink
solubility   DMSO: ≥20 mg/mL
storage temp.   2-8°C
SMILES string   Cc1[nH]c2ccccc2c1CCNC(=O)c3cccs3

Description

Biochem/physiol Actions

CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-636 inserts into the hydrophobic core of Arp3 and alters its conformation. Both classes of compounds inhibit formation of actin filament comet tails by Listeria and podosomes by monocytes.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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