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C7802 Sigma

Charybdotoxin

≥90% (HPLC)

  • CAS Number 95751-30-7

  • Empirical Formula (Hill Notation) C176H277N57O55S7

  • Molecular Weight 4295.89

  •  MDL number MFCD00146378

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Description

Amino Acid Sequence

Glp-Phe-Thr-Asn-Val-Ser-Cys-Thr-Thr-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Gln-Arg-Leu-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys-Met-Asn-Lys-Lys-Cys-Arg-Cys-Tyr-Ser [Disulfide Bridges: 7-28, 13-33, 17-35]

Application

Charybdotoxin has been used:
• in the inhibition of endothelium-derived hyperpolarizing factor responses
• in electrophysiological studies, as calcium channel blockers
• as a transport inhibitor

Biochem/physiol Actions

Charybdotoxin (ChTX) is a scorpion venom, which blocks a voltage-gated potassium channel, by binding to the extracellular loop of the potassium channel.

High (BK) or intermediate (IK1) conductance calcium-activated and voltage-gated (Kv1.3) channel blocker.

Potent and selective inhibitor of the Ca2+-activated K+ channel present in GH3 anterior pituitary cells and primary bovine aortic smooth muscle cells.

Other Notes

Peptide found in the venom of the scorpion Leiurus quinquestriatus.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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