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C7912 Sigma-Aldrich

Cefotaxime sodium salt

potency: 916-964 μg per mg

Synonym: Cefotaxim sodium salt

  • CAS Number 64485-93-4

  • Empirical Formula (Hill Notation) C16H16N5NaO7S2

  • Molecular Weight 477.45

  •  Beilstein Registry Number 5711411

  •  EC Number 264-915-9

  •  MDL number MFCD00079073

  •  PubChem Substance ID 24278336

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics by Mechanism of Action,
InChI Key   AZZMGZXNTDTSME-JUZDKLSSSA-M
form   powder
potency   916-964 μg per mg
solubility   H2O: 50 mg/mL
Mode of action   cell wall synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C

Description

Other Notes

Broad spectrum third generation cephalosporin antibiotic.

Keep container tightly closed in a dry and well-ventilated place.

Application

Cefotaxim has been used to find new residues involved in cefotaxime hydrolysis in CTX-M β-lactamases, to study antibiotic-susceptible and -resistant Streptococcus pneumoniae infections, and to study pneumococcal pneumonia and the pharmokinetics of various treatments. It may be used to study the effects of binding and inhibition of penicillin binding protein 2 (PBP2) on bacterial mucopeptide synthesis.

Biochem/physiol Actions

Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.

General description

Chemical structure: ß-lactam

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
XI0250000
Protocols & Articles

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Peer-Reviewed Papers
15

References

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