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C8032 Sigma-Aldrich

α-Casein Dephosphorylated from bovine milk

lyophilized powder

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Properties

Related Categories Biochemicals and Reagents, Casein and Other Milk Proteins, Proteins and Derivatives More...
Quality Level   200
biological source   bovine milk
assay   ≥70% (biuret)
form   lyophilized powder
application(s)   surface plasmon resonance (SPR): suitable
storage temp.   −20°C
Gene Information   bovine ... MACAS(100532647), MACASP(105753520)

Description

Application

α-Casein from bovine milk is an Immunoglobulin E (IgE)-binding epitope belonging to the Casein phosphoprotein family. It has been used in studies of children with insulin-dependent diabetes mellitus (IDDM), due to the strong cross-reactivity of α-casein antibodies with insulin. Studies of children displaying (IDDM) show higher levels of α-casein antibodies than control siblings, which may serve as a risk marker for IDDM.

Packaging

1 g in poly bottle

100, 250 mg in poly bottle

Biochem/physiol Actions

Clusters of phosphoserine in casein chelate iron and reduce its bioavailability. Partial enzymatic digestion of casein unmasks phosphorylated residues to alkaline phosphatase, permitting dephosphorylation and increasing the bioavailability of iron.

Quality

At least 80% dephosphorylated.

Preparation Note

Enzymatically prepared from C6780.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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