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C8138 Sigma-Aldrich

Chlorpromazine hydrochloride

≥98% (TLC)

Synonym: 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil

  • CAS Number 69-09-0

  • Empirical Formula (Hill Notation) C17H19ClN2S · HCl

  • Molecular Weight 355.33

  •  Beilstein/REAXYS Number 3779989

  •  EC Number 200-701-3

  •  MDL number MFCD00012654

  •  PubChem Substance ID 57654045

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Description

Application

Chlorpromazine hydrochloride has been used:
• as an antagonists for calmodulin kinase
• as a medium supplement to test its cytotoxic effects in human lung microvascular endothelial cells (HMVEC-L)
• as an inhibitor of clathrin-mediated endocytosis in RAW 264.7 cells

Substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase.

Packaging

5, 25, 100 g in glass bottle

Biochem/physiol Actions

Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.

Phenothiazine antipsychotic; D2 dopamine receptor antagonist, H1 histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811PIH 6.1 / PGI
WGK Germany 
3
RTECS 
SO1750000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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