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C8352 Sigma-Aldrich

Anti-CXCR4 (Fusin) (182-196) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies against Proteins/Bioactives/Markers/Receptors for Stem Cell Biology, Antibodies for Cell Biology, Antibodies for Hematopoietic Stem Cells,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   western blot: 0.5-1 μg/mL using human HeLa cell extract
species reactivity   human
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   IgG fraction of antiserum
antibody product type   primary antibodies
UniProt accession no.   P61073
Gene Information   human ... CXCR4(7852)

Description

General description

Chemokine receptor CXCR-4 also refers as fusin or LESTR is a protein that belongs to G-protein coupled receptor 1 family. It is an essential cofactor for T cell-tropic HIV viruses into CD4+ cells. N-Terminal domain and second extracellular loop of the protein act as a HIV binding sites. Anti-CXCR4 (Fusin) (182-196) antibody can be used to block HIV-1 and HIV-2 fusion and infection of human target cells. Rabbit anti-CXCR4 (Fusin) (182-196) antibody reacts specifically with human CXCR4.

Immunogen

synthetic peptide corresponding to amino acids 182-196 of the second extracellular loop of human CXCR4.

Application

Anti-CXCR4 (Fusin) (182-196) antibody may be used in immunoblotting at a working antibody concentration of 0.5 - 1 μg/ml using human HeLa cell extract. It can also be used in immunohistochemistry.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Other Notes

The antigen (receptor) is also termed fusin, LESTER and HUMSTR.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
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Cancer Stem Cells: New Targets for Cancer Therapy

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Keywords: Cancer, Cell attachment, Cell culture, Cell proliferation, Gastrointestinal, Gene expression, Transcription, transformation

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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