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C8395 Sigma-Aldrich

Cephradine

≥90.0% (Cephradine, HPLC)

Synonym: Cefradin

  • CAS Number 38821-53-3

  • Empirical Formula (Hill Notation) C16H19N3O4S

  • Molecular Weight 349.40

  •  MDL number MFCD00865048

  •  PubChem Substance ID 24278342

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics by Mechanism of Action,
InChI Key   RDLPVSKMFDYCOR-UEKVPHQBSA-N
assay   ≥90.0% (Cephradine, HPLC)
form   powder
solubility   ethanol: practically insoluble 96%
  hexane: practically insoluble
  water: slightly soluble
Mode of action   cell wall synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C

Description

Application

Cefradin was used to study the effect of expression, binding, and inhibition of PBP3 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.

Biochem/physiol Actions

Cefradin is a semi-synthetic cephalosporin that inhibits the last stage of bacterial cell wall synthesis by binding to certain penicillin-binding proteins (PBPs), such as PBP3, which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. It is effective against Gram-positive and Gram-negative bacteria. Cefradin may also interfere with autolysin inhibitors.

General description

Chemical structure: ß-lactam

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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