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C8912 Sigma-Aldrich

Cocaine free base

Synonym: Ecgonine methyl ester benzoate

  • CAS Number 50-36-2

  • Empirical Formula (Hill Notation) C17H21NO4

  • Molecular Weight 303.35

  •  EC Number 200-032-7

  •  MDL number MFCD00056906

  •  PubChem Substance ID 24893116

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   200
drug control   USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IB (Portugal)
Featured Industry   Forensics and Toxicology
SMILES string   [H][C@]12CC[C@]([H])([C@H]([C@H](C1)OC(=O)c3ccccc3)C(=O)OC)N2C
InChI   1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14-,15+/m0/s1
InChI key   ZPUCINDJVBIVPJ-LJISPDSOSA-N
Gene Information   human ... DRD3(1814), KCNH1(3756), KCNH2(3757), SCN10A(6336), SCN11A(11280), SCN5A(6331), SLC6A2(6530), SLC6A3(6531), SLC6A4(6532)
mouse ... Slc6a2(20538)
rat ... Chrm1(25229), Slc6a3(24898), Slc6a4(25553)

Description

Biochem/physiol Actions

Inhibits the dopamine, norepinephrine, and serotonin transporters with Kis of about 300 nM, 900 nM, and 400 nM, respectively. Unlike amphetamines, it has no effect on catecholamine release.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Central nervous system
RIDADR 
UN 1544PSN1 6.1 / PGIII
WGK Germany 
WGK 3
RTECS 
YM2800000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

HPLC Analysis of Tetramisole Enantiomers and Related Compounds on Astec® CYCLOBOND® I 2000 DMP

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Tetramisole Enantiomers and Related Compounds on Astec® CYCLOBOND® I 2000 DMP
Keywords: Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites, Pharmaceutical, Separation, Solvents

LC/MS Analysis of Illicit Drugs and Metabolites on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Illicit Drugs and Metabolites on Ascentis® Express RP-Amide
Keywords: Chromatography, Forensic, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Separation

Peer-Reviewed Papers
15

References

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