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C9373 Sigma-Aldrich

CP-96345

≥98% (HPLC)

Synonym: (2S,3S)-cis-2-(Diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine

  • CAS Number 132746-60-2

  • Empirical Formula (Hill Notation) C28H32N2O

  • Molecular Weight 412.57

  •  MDL number MFCD00900615

  •  PubChem Substance ID 329775205

  •  NACRES NA.77

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, CI-CZ,
assay   ≥98% (HPLC)
form   white powder
solubility   DMSO: 24 mg/mL
originator   Pfizer
storage temp.   room temp
SMILES string   COC1=CC=CC=C1CN[C@@H]2[C@H](C(C3=CC=CC=C3)C4=CC=CC=C4)N5CCC2CC5
InChI   1S/C28H32N2O/c1-31-25-15-9-8-14-24(25)20-29-27-23-16-18-30(19-17-23)28(27)26(21-10-4-2-5-11-21)22-12-6-3-7-13-22/h2-15,23,26-29H,16-20H2,1H3/t27-,28-/m0/s1
InChI key   FLNYLINBEZROPL-NSOVKSMOSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

CP-96345 is a selective NK1 antagonist. CP96345 inhibits substance P-induced salivation in the rat by classical in vivo bioassay, but did not inhibit NK2, NK3, or numerous other receptors.

Features and Benefits

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Tachykinin Receptors

The tachykinins represent a large family of peptides whose common structural feature is the C-terminal amino acid sequence Phe-X-Gly-Leu-Met-NH2. Substance P (SP), neurokinin A (NKA), neurokinin B (N...
Keywords: Atomic absorption spectroscopy, Clinical, Diseases, Gastrointestinal, Gene expression, Inflammation, Neurotransmission, Schizophrenia, Transduction

Peer-Reviewed Papers
15

References

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