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C9625 Sigma

L-Carnosine

~99%, crystalline

Synonym: β-Alanyl-L-histidine

  • CAS Number 305-84-0

  • Empirical Formula (Hill Notation) C9H14N4O3

  • Molecular Weight 226.23

  •  Beilstein Registry Number 87671

  •  EC Number 206-169-9

  •  MDL number MFCD00005207

  •  PubChem Substance ID 24893178

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Properties

Related Categories Amino Acid, Amino acids, Cell Biology, Functional Foods, Metabolic Pathways,
InChI Key   CQOVPNPJLQNMDC-ZETCQYMHSA-N
assay   ~99%
form   crystalline
mp   253 °C (dec.)(lit.)
storage temp.   −20°C
Gene Information   human ... CA1(759), CA2(760)

Description

Amino Acid Sequence

Ala-His

Packaging

10 mg in poly bottle

5, 25, 100 g in poly bottle

Application

L-Carnosine has been used to study its effects as an antioxidant on meat quality of pigs. It has also been used to study its effects on brain injury in a rat intracerebral hemorrhage model.

Biochem/physiol Actions

L-Carosine is a dipeptide found at millimolar concentration in brain, muscle and the lens of the eye. In model systems it is a potent antioxidant that scavenges oxygen free radicals and transition metal ions. It blocks protein-protein and protein-DNA cross-links induced by hypochlorite anions and toxic aldehydes such as acetaldehyde, formaldehyde, and malondialdehyde, the primary product of lipid peroxidation. It also inhibits nonenzymatic protein glycation induced by aldose and ketose reducing sugars and inhibits the formation of toxic advanced glycation end products (AGE). These activities make it of interest in studies of aging, atherosclerosis, Alzheimer′s disease, and the secondary effects of diabetes.

Dipeptide with potent antioxidant and antiglycation activity; blocks nonenzymatic glycosylation and protein cross-linking induced by reactive aldehydes.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C9625.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Making Headway
Protocols & Articles

Articles

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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