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C9750 Sigma-Aldrich

β-Carotene

synthetic, ≥93% (UV), powder

Synonym: β,β-Carotene, Provitamin A

  • CAS Number 7235-40-7

  • Empirical Formula (Hill Notation) C40H56

  • Molecular Weight 536.87

  •  Beilstein/REAXYS Number 1917416

  •  EC Number 230-636-6

  •  MDL number MFCD00001556

  •  PubChem Substance ID 24893189

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Properties

Related Categories Antioxidant and Free Radical Scavengers, Biochemicals and Reagents, Cancer Research, Carotenoid, Cell Biology,
biological source   synthetic
InChI Key   OENHQHLEOONYIE-JLTXGRSLSA-N
assay   ≥93% (UV)
form   powder
potency   ~1,600,000 units vitamin A per g
color   dark red to brown
mp   178-179 °C
solubility   hexane: 1.1 mg/mL
  DMSO: 30 μg/mL
storage temp.   2-8°C

Description

General description

Carotenoids are an important class of naturally occurring pigments found in fruits and vegetables. Among the carotenoids, β-carotene has the greatest provitamin A potential and functions to reduce the risk of cancer, cardiovascular diseases and macular degeneration. Low water solubility and poor chemical stability attributes to low absorption of β-carotene from food. β-carotene along with digestible lipids enriches its bio accessibility. Emulsions or nano emulsions encapsulates effectively delivers lipophilic β-carotene and increases its bioavailability. β-carotene has anti-oxidant potential and reduces noise induced hearing loss and progression of macular degeneration.

Application

β-carotene has been used:
• to generate nano emulsions to evaluate their bioavailability potential
• as a standard, for β-carotene evaluation in blood and skin samples using high performance liquid chromatography (HPLC),
• as a dietary supplement of vitamin-A in young rats by HPLC
• as a dietary supplement in mice to reduce hearing loss and hair cell damage

Packaging

5, 10, 25 g in glass bottle

Biochem/physiol Actions

The most important of the provitamins A, β-carotene can be classified as an antioxidant due to its inhibition of radical initiated peroxidation in vitro. However, in vivo it appears to act either as an antioxidant or a prooxidant depending on cellular environment. It reduces the incidence of many cancers, but enhances lung cancer incidence in smokers.

Packaging

Packaged in serum vials.

Caution

Purchase minimum quantity required. Discard one month after opening.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C9750.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

Supplemental Hazard Statements 
Risk of explosion if heated under confinement.
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
FI0329500
Flash Point(F) 
217.4 °F
Flash Point(C) 
103 °C

Documents

Certificate of Analysis

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Certificate of Origin

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
Biofiles Volume 2 Article 2
Keywords: Adhesion, Anti-inflammatory agents, Applications, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

Retinoic Acid and Gene Expression

All-trans retinoic acid (RA, ATRA) is a pleiotropic activation factor that regulates genes associated with normal vertebrate cellular processes such as cell differentiation, cell proliferation, apopt...
BioFiles 2008, 3.9, 12.
Keywords: Apoptosis, Cancer, Cell proliferation, Cellular processes, Chromatin immunoprecipitation, Condensations, Degradations, Diseases, Gene expression, Hormones, Immunoprecipitation, Ligands, Metabolism, Oxidations, Phosphorylations, Polymerase chain reaction, Sequences, Teratogens, Transcription, Type, Ubiquitinations, Usage, Vitamins

Peer-Reviewed Papers
15

References

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