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  • C9979 - Monoclonal Anti-CD152 antibody produced in mouse

C9979 Sigma

Monoclonal Anti-CD152 antibody produced in mouse

~1 mg/mL, clone AS32, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-CTLA-4



Related Categories Alphabetical Index, Analytical Cytology, Antibodies, Antibodies for Cell Biology, Antibodies for Immune Cell Signaling and Blood,
species reactivity   human
application(s)   neutralization: suitable
  western blot: suitable
clone   AS32, monoclonal
concentration   ~1 mg/mL
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG1
shipped in   wet ice
storage temp.   2-8°C
Gene Information   human ... CTLA4(1493)
biological source   mouse
conjugate   unconjugated



recombinant extracellular domain of human CD152.

General description

CD152 is structurally similar to CD28 and is a member of the immunoglobin (Ig) gene superfamily. The gene encoding human CD152 is present on chromosone 2. It is composed of a single Ig V-like extracellular domain, a transmembrnne domain, and an intracellular domain. It is mainly expressed by cytotoxic T lymphocytes and the level of expression is activation-dependent.

Antigen Background

CD152, a cell surface glycoprotein, is one of two ligands (the other is CD28) for CD80 (B7-1) and CD86 (B7-2). This interaction appears to function as a negative regulator to T cell activation. CD152 is transiently expressed on activated T cells.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 0.08% sodium azide.

Preparation Note

Prepared from tissue culture supernatant, purified using protein G.


Monoclonal Anti-CD152 antibody produced in mouse is suitable for western blotting and for neutralization studies, where this antibody has been shown to block the interaction of soluble human CD152 with human CD80.

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Biochem/physiol Actions

CD152 and CD28 together with their ligands constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. CD152 acts as a co-stimulatory molecule in eliciting T cell help during antigen presentation and functions as a negative regulator of T cell activation.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy


Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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