EMAIL THIS PAGE TO A FRIEND
D048 Sigma-Aldrich

MPP+ iodide

≥98% (HPLC), powder

Synonym: 1-Methyl-4-phenylpyridinium iodide

Purchase

Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Dopaminergics,
InChI Key   RFDFRDXIIKROAI-UHFFFAOYSA-M
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to beige
solubility   H2O: 10 mg/mL, clear

Description

Caution

Photosensitive.

Packaging

1 g in glass bottle

100 mg in glass bottle

Preparation Note

Solutions should be freshly prepared.

Application

MPP+ iodide has been used:
• to induce oxidative stress in zebrafish embryos
• for the inhibition of glutamate uptake in mitochondria of astrocytes
• in testing cell viability using MTT (3 (4,5-dimethylthiazol)-2-yl-2,5-diphenyltetrazolium bromide) in microglia (BV2) cells

Biochem/physiol Actions

MPP+ iodide is an active metabolite of dopaminergic neurotoxin MPTP.

General description

1-Methyl-4-phenylpyridinium (MPP+) induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3
RTECS 
UU6580000

Documents

Certificate of Analysis


Same Products - New Packaging
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?