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D0564 Sigma-Aldrich

Diphtheria Toxin from Corynebacterium diphtheriae

lyophilized powder, Product is in unnicked form

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Description

Application

Diphtheria toxin may be used as a toxin element in the construction of immunotoxin for cell specific cytotoxicity. The translocation domain of bacterial toxins with natural endosome escape mechanism has been used in the development of efficient nonviral vectors for applications in gene therapy.

Biochem/physiol Actions

Inhibits protein synthesis by catalyzing ADP-ribosylation of eukaryotic aminoacyltransferase II.

Physical form

Lyophilized powder containing Tris and EDTA.

Reconstitution

Each vial, when reconstituted to 0.5 mL with sterile distilled water, contains ~1 mg of diphtheria toxin in 0.01 M Tris and 0.001 M Na2EDTA, pH 7.5.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
RIDADR 
UN 3462 6.1 / PGI
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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