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  • D0627 - N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt

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D0627 Sigma-Aldrich

N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt

≥96% (HPLC), powder

Synonym: Bucladesine sodium salt, Dibutyryl cAMP sodium salt, Dibutyryl cyclic-AMP sodium salt

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Core Bioreagents, Cyclic Nucleotide Metabolism,
Quality Level   200
biological source   synthetic (organic)
assay   ≥96% (HPLC)
form   powder
impurities   ≤0.5% Cyclic AMP
  ≤3% monobutyryl derivatives
color   off-white
solubility   H2O: 50 mg/mL
storage temp.   −20°C
SMILES string   [Na+].CCCC(=O)Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3OC(=O)CCC
InChI   1S/C18H24N5O8P.Na/c1-3-5-11(24)22-16-13-17(20-8-19-16)23(9-21-13)18-15(30-12(25)6-4-2)14-10(29-18)7-28-32(26,27)31-14;/h8-10,14-15,18H,3-7H2,1-2H3,(H,26,27)(H,19,20,22,24);/q;+1/p-1/t10-,14-,15-,18-;/m1./s1
InChI key   KRBZRVBLIUDQNG-JBVYASIDSA-M

Description

Application

Dibutyryl CAMP is a cell-permeable CAMP analogue that activates CAMP dependent protein kinase (PKA) or the CAMP/PKA signaling pathway. Dibutyryl CAMP is used as a morphological differentiation inducer and cell signaling modulator in cells such as Schwann cells. Dibutyrl cAMP is used in a variety of differentiation studies, such as neuron differentiation / neuronal differentiation.

Packaging

1 g in poly bottle

25, 100, 250 mg in poly bottle

Biochem/physiol Actions

Cell-permeable cAMP analog that activates cAMP dependent protein kinase (PKA).

Caution

Loses 2′-O-butyryl group at pH 8.5

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
RTECS 
ES5055500
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Chondroitinase for Neural Regeneration Research

The spinal cord is the information highway system for the brain. And axons are the road that allows information data to be transferred. So, when a traumatic spinal cord injury (SCI) occurs and axons ...
Keywords: Catalysis, Cell culture, Degradations, High performance liquid chromatography, Immunofluorescence, PAGE

Protocols

Neural Stem Cell Culture Protocols

Introduction Methods     Isolation of Neural Stem Cells         Isolation of NSCs from Neural Tissue         Differentiation of Human iPSCs into NSCs         Characterization of Neural Stem Cells    ...
Keywords: AGE, Adhesion, Apoptosis, Cell culture, Central Nervous System, Cryopreservation, Culture media, Diseases, Growth factors, High performance liquid chromatography, Phase transitions, Phosphorylations, Purification

Peer-Reviewed Papers
15

References

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