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D0676 Sigma-Aldrich

Dobutamine hydrochloride

≥98%

Synonym: (±)-3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenethylamine hydrochloride

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Properties

Related Categories Adrenergics, Adrenergics - Agonists, Agonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index,
Quality Level   200
assay   ≥98%
originator   Eli Lilly
storage temp.   2-8°C
SMILES string   Cl[H].CC(CCc1ccc(O)cc1)NCCc2ccc(O)c(O)c2
InChI   1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H
InChI key   BQKADKWNRWCIJL-UHFFFAOYSA-N
Gene Information   human ... ADRB1(153), ADRB2(154)

Description

Application

Dobutamine hydrochloride has been used:
• to treat mouse embryonic fibroblasts for cell death analysis
•  to inhibit TAZ (transcriptional coactivator with PDZ-binding motif)/YAP (Yes-associated protein) of Hippo pathway and study its effect on tumor cell proliferation
•  as β1-AR partial agonist to determine its effects on budding of endophilin-mRFP-positive structures by live-cell imaging

Biochem/physiol Actions

Dobutamine is a synthetic catecholamine that stimulate the β1 -adrenoceptor receptor. It exhibits inotropic outcome on the myocardium. Dobutamine elevates contractility and is known to be useful in the condition of low blood pressure.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Protocols & Articles
Peer-Reviewed Papers
15

References

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