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D101 Sigma

(±)-DOI hydrochloride

≥98% (HPLC), solid

Synonym: (±)-DOI, (±)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride, (±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride

  • CAS Number 42203-78-1

  • Empirical Formula (Hill Notation) C11H16INO2 · HCl

  • Molecular Weight 357.62

  •  MDL number MFCD00055199

  •  PubChem Substance ID 24278092

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Properties

Related Categories Agonists, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators,
InChI Key   QVFDMWGKHUFODK-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   solid
drug control   Home Office Schedule 1regulated under CDSA - not available from Sigma-Aldrich Canada
color   white to off-white
solubility   H2O: 10 mg/mL
  ethanol: 2 mg/mL
Gene Information   human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)

Description

Packaging

10 mg in glass bottle

25 mg in poly bottle

100, 500 mg in glass bottle

Biochem/physiol Actions

(±)-DOI hydrochloride is a potent and selective 5-HT2 serotonin receptor agonist that crosses the blood-brain barrier, increases dopamine turnover and the treatment with DOI counteracted the expression of the nicotine-induced locomotor and neurochemical sensitization, but had no effect on nicotine-induced behavioral disinhibition. The responses to DOI provide evidence that of these receptors are abundant in the cortex, and show relatively lower levels in hippocampus and cerebellum.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin


Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

LC/MS (TOF) Analysis of 2C Amines Drugs of Abuse in Urine on Ascentis® Express HILIC after Solid Phase Extraction (SPE) using Supel™-Select SCX

From our library of Articles, Sigma-Aldrich presents LC/MS (TOF) Analysis of 2C Amines Drugs of Abuse in Urine on Ascentis® Express HILIC after Solid Phase Extraction (SPE) using Supel™-Select SCX
Keywords: Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Sample preparations, Solid phase extractions

LC/MS Analysis of 2C Amines Drugs of Abuse on Ascentis® Express HILIC

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of 2C Amines Drugs of Abuse on Ascentis® Express HILIC
Keywords: Chromatography, Clinical, High performance liquid chromatography, Mass spectrometry

Peer-Reviewed Papers
15

References

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