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D1047 Sigma

N,N-Dimethylsphingosine

≥95%

Synonym: (2S,3R,4E)-2-(Dimethylamino)-4-octadecene-1,3-diol, N,N-Dimethyl-D-erythro-sphingosine, N,N-Dimethylsphingenine

  • CAS Number 119567-63-4

  • Empirical Formula (Hill Notation) C20H41NO2

  • Molecular Weight 327.55

  •  MDL number MFCD00153960

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Properties

InChI Key   YRXOQXUDKDCXME-QWKHPXNBSA-N
assay   ≥95%
concentration   ~1 mg/mL in ethanol (Actual concentration given on label)
storage temp.   −20°C

Description

Biochem/physiol Actions

General modulator of protein kinases; inhibits protein kinase C and stimulates src kinase; induces apoptosis in human leukemia HL-60 cells. Sphingosine kinase inhibitor.

Preparation Note

Prepared from D-sphingosine.

Application

Dimethylsphingosine is a potent inhibitor of sphingosine kinase; able to induce apoptosis in drug-resistant human UMCC-1/VP SCLC cells and to amplify the apoptogenic effects of selected chemotherapeutic agents.

Safety & Documentation

Safety Information

RIDADR 
UN 1170 3/PG 2
WGK Germany 
1
Flash Point(F) 
57 °F
Flash Point(C) 
14 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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