EMAIL THIS PAGE TO A FRIEND
D1064 Sigma-Aldrich

Dihydrokainic acid

≥98% (HPLC), powder

Synonym: 2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid

  • CAS Number 52497-36-6

  • Empirical Formula (Hill Notation) C10H17NO4

  • Molecular Weight 215.25

  •  MDL number MFCD03412037

  •  PubChem Substance ID 24277981

  •  NACRES NA.77

Purchase

Properties

Related Categories AMPA/Kainate Antagonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
solubility   H2O: >10 mg/mL
storage temp.   2-8°C
SMILES string   CC(C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
InChI   1S/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
InChI key   JQPDCKOQOOQUSC-OOZYFLPDSA-N
Gene Information   human ... SLC1A1(6505), SLC1A2(6506), SLC1A3(6507)
rat ... Slc1a2(29482), Slc1a3(29483)

Description

Application

Dihydrokainic acid has been used as a glutamate transporter (GLT-1) inhibitor in the glutamate uptake assay of astrocytes and glial cells. It may be used as a GLT-1 inhibitor in Lateral habenula (LHb).

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Dihydrokainic acid is a selective inhibitor of the GLT-1 glutamate transporter. At higher concentrations, dihydrokainate is a weak inhibitor of AMPA/kainate glutamic acid receptors.

Dihydrokainic favors neuronal cell death. It modulates anxiety and depression behaviors.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Excitatory Amino Acid Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?