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D1068 Sigma-Aldrich

DCB

≥98% (HPLC), solid

Synonym: 3,3′-Dichlorobenzaldazine, NSC 67224

  • CAS Number 6971-97-7

  • Empirical Formula (Hill Notation) C14H10Cl2N2

  • Molecular Weight 277.15

  •  MDL number MFCD00556081

  •  PubChem Substance ID 24724458

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, D-DIF,
InChI Key   XMOVWXSCYLINBJ-BEQMOXJMSA-N
Quality Level   100
assay   ≥98% (HPLC)
form   solid
storage condition   desiccated
  under inert gas
color   yellow
solubility   DMSO: ~6.8 mg/mL
  H2O: insoluble
storage temp.   2-8°C

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

3,3′-dichlorobenzaldazine (DCB) serves as an allosteric ligand with neutral cooperativity. It helps to block the positive allosteric regulation of mGluRs (metabotropic glutamate receptor subtype 5 (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB) and the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB).

Neutral allosteric modulator of the metabotropic glutamate receptor mGluR5.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Method 508A - Determination of Chlorinated Pesticides in Water

Products listed below are for use in EPA Method 508A: "Screening for Polychlorinated Biphenyls by Perchlorination and Gas Chromatography."
Keywords: Chromatography, Gas chromatography

Peer-Reviewed Papers
15

References

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