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D1414 Sigma-Aldrich

Droperidol

Synonym: 1-[1-[3-(p-Fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl]-2-benzimidazolinone

  • CAS Number 548-73-2

  • Empirical Formula (Hill Notation) C22H22FN3O2

  • Molecular Weight 379.43

  •  EC Number 208-957-8

  •  MDL number MFCD00083290

  •  PubChem Substance ID 24278357

  •  NACRES NA.77

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Properties

Related Categories Antagonists - Dopaminergics, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents,
originator   Johnson & Johnson
storage temp.   2-8°C
SMILES string   Fc1ccc(cc1)C(=O)CCCN2CCC(=CC2)N3C(=O)Nc4ccccc34
InChI   1S/C22H22FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-11H,3,6,12-15H2,(H,24,28)
InChI key   RMEDXOLNCUSCGS-UHFFFAOYSA-N
Gene Information   human ... DRD1(1812), DRD2(1813), KCNH1(3756), KCNH2(3757)

Description

Biochem/physiol Actions

D1, D2 dopamine receptor antagonist; butyrophenone antipsychotic and anti-emetic.

Droperidol is a potent antagonist of dopamine subtype 2 receptor. It is an antipsychotic, which is used to treat acute behavioral anomalies. It helps to manage postoperative nausea and vomiting.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
DE2100000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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