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D1415 Sigma-Aldrich

4,6-Dioxoheptanoic acid

powder

Synonym: Succinylacetone

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Properties

Related Categories Biochemicals and Reagents, Core Bioreagents, Fatty Acids and conjugates, Fatty Acyls, Keto fatty acids,
InChI Key   WYEPBHZLDUPIOD-UHFFFAOYSA-N
form   powder
mp   66-67 °C (lit.)
storage temp.   2-8°C

Description

Application

4,6-Dioxoheptanoic acid has been used:
• as component of dendritic cell conditioning medium and in the inhibition of ALA dehydratase (ALAD) in dendritic cells(50)
• as an inhibitor of heme biosynthesis in human mononuclear cells(51) and HeLa cells(52)
• as a standard for the quantification of succinylacetone from Plasmodium falciparum cultures(53)

Packaging

1 g in glass bottle

100, 500 mg in glass bottle

Biochem/physiol Actions

4,6-Dioxoheptanoic acid is an inhibitor of heme biosynthesis. It is a catabolic byproduct of tyrosine breakdown and inhibits δ-aminolevulinic acid (ALA) dehydratase enzyme. It is a potential marker for detecting tyrosinemia type I and is measured in dried blood spot of new borns.

An inhibitor of heme biosynthesis

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. D1415.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Single- & multi-channel pipettes from BRAND
Protocols & Articles

Articles

OAMLS Online Plate Map

OAMLS compounds are conveniently provided at 5µg per well, enough for multiple injections. These are high purity (>95%) compounds supplied in an economical, ready to use format. Compounds are arrange...
Keywords: Metabolites

Peer-Reviewed Papers
15

References

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