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  • D1694 - Anti-DYRK1A (N-terminal) antibody produced in rabbit

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D1694 Sigma-Aldrich

Anti-DYRK1A (N-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Dual-specificity tyrosine-phosphorylation-regulated kinase 1A, Anti-MBN/MNBH, Anti-MNB protein kinase, Anti-Minibrain Drosophila homolog

  •  NACRES NA.41

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, Antibodies for Neurobiology,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   western blot: 1.5-3 μg/mL using rat brain embryonic extract (S1 fraction)
  western blot: 3-5 μg/mL using PC12 cell lyste
species reactivity   rat, mouse, human
mol wt   antigen ~86 kDa
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   200
antibody product type   primary antibodies
concentration   ~1.5 mg/mL
UniProt accession no.   Q13627
Gene Information   human ... DYRK1A(1859)
mouse ... Dyrk1a(13548)
rat ... Dyrk1a(25255)

Description

General description

DYRK1A (dual-specificity tyrosine-phosphorylated regulated kinase 1A) is a member of a growing family of Ser/Thr protein kinases termed DYRKs.

The human and rodent DYRK1A are ubiquitously expressed in adult and fetal tissue with high expression in the brain and heart during development.

Application

Anti-DYRK1A (N-terminal) antibody produced in rabbit has been used in immunoblotting and immunohistochemistry.

Target description

DYRK1A (N-terminal) encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-c

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

DYRK1A is encoded by a gene located within the Down syndrome (DS) critical region on human chromosome 21 and its expression is found to be elevated in individuals with DS. It might be one of the genes involved in some of the neurological abnormalities observed in DS. It phosphorylates several substrates including transcription factor FKHR, NFAT, STAT3, microtubule-associated protein Tau, glycogen synthase and c-AMP-response element-binding protein.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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