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D2043 Sigma-Aldrich

Defensin HNP-1 human

≥80% (HPLC)

Synonym: Neutrophil Peptide-1

  • CAS Number 99287-08-8

  • Empirical Formula (Hill Notation) C150H222N44O38S6

  • Molecular Weight 3442.03

  •  MDL number MFCD00214572

  •  PubChem Substance ID 329798727

  •  NACRES NA.32

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Properties

Related Categories A - K, Antibacterial, Antibiotic Peptides, Antibiotics, Antibiotics A to Z,
InChI Key   KRJOFJHOZZPBKI-KSWODRSDSA-N
Quality Level   200
assay   ≥80% (HPLC)
composition   Peptide content, ~70%
solubility   water: 1 mg/mL, clear, colorless
Mode of action   cell membrane | interferes
antibiotic activity spectrum   fungi
  mycobacteria
  viruses
storage temp.   −20°C
Gene Information   human ... DEFA1(1667)

Description

Amino Acid Sequence

Ala-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys [Disulfide bridges: 2−30; 4−19; 9−29]

General description

Chemical structure: peptide

The α-defensin genes, such as DEFA1 (defensin alpha 1) and DEFA3 (defensin α 3) codes for HNP-1, 2 and 3 (human neutrophil peptides). This gene is mapped to human chromosome 8p23.1.

Biochem/physiol Actions

Human neutrophil peptides (HNPs) is involved in endothelial cell dysfunction at the time of early atherosclerotic development. HNP 1−3 can regulate the growth of atherosclerosis. HNP 1−3 levels are usually high in inflammation, including sepsis and acute coronary vascular disorders.

This is an endogenous antibiotic peptide and monocyte chemotactic peptide produced by human neutrophils. Defensins are a family of 3-4 kDa (29-34 amino acids) peptides found in the granules of mammalian phagocytes. The members of this family are variably arginine-rich and share six conserved cysteine residues that participate in intramolecular disulfide bonds.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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