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D2069 Sigma-Aldrich

Desvenlafaxine hydrochloride

≥98% (HPLC), powder

Synonym: 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-phenol hydrochloride

  • CAS Number 300827-87-6

  • Empirical Formula (Hill Notation) C16H25NO2 · HCl

  • Molecular Weight 299.84

  •  MDL number MFCD11045287

  •  PubChem Substance ID 329798729

  •  NACRES NA.77

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Properties

Related Categories Adrenergics, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to off-white
solubility   DMSO: >20 mg/mL
  H2O: >20 mg/mL
originator   Wyeth
storage temp.   2-8°C
SMILES string   Cl.CN(C)CC(c1ccc(O)cc1)C2(O)CCCCC2
InChI   1S/C16H25NO2.ClH/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16;/h6-9,15,18-19H,3-5,10-12H2,1-2H3;1H
InChI key   IMWPSXHIEURNKZ-UHFFFAOYSA-N

Description

Application

Desvenlafaxine hydrochloride has been used to evaluate if its occurrence in drinking water at environmental concentrations could induce neuronal gene expression.

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Desvenlafaxine hydrochloride is a dual SERT/NET reuptake inhibitor. It is a major active metabolite of venlafaxine (#542); brain penetrant; Ki = 40 nM and 122 nM for hSERT and hNET, respectively (weak binding at the hDAT). Inhibition of [3H]5-HT or [3H]NE uptake for the hSERT or hNET produced IC50 values of 47 and 531 nM.

Desvenlafaxine hydrochloride is a psychoactive drug. Incidence of this drug in environmental samples might induce in vitro gene expression associated with neurological disorders.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Biogenic Amine Transporters

Following vesicular release, the biogenic amine neurotransmitters, norepinephrine (A7257), dopamine (H8502) and serotonin (H9523), are removed from the extracellular space by selective and pharmacolo...
Keywords: Anti-depressants, Atomic absorption spectroscopy, Clinical, Cloning, Gene expression, Ligands, Neurotransmission, Neurotransmitters, Parkinson Disease, Phosphorylations, Schizophrenia

Peer-Reviewed Papers
15

References

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