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D2625 Sigma-Aldrich

Dansyl chloride

BioReagent, suitable for amino acid labeling, powder and chunks, ≥99% (HPLC)

Synonym: 5-(Dimethylamino)naphthalene-1-sulfonyl chloride, DNSCl

  • CAS Number 605-65-2

  • Empirical Formula (Hill Notation) C12H12ClNO2S

  • Molecular Weight 269.75

  •  Beilstein/REAXYS Number 2217205

  •  EC Number 210-092-6

  •  MDL number MFCD00003985

  •  PubChem Substance ID 24893700

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Properties

Related Categories Amino Acid Analysis, Biochemicals and Reagents, Detection Products for Amino Acid Analysis, Peptide Analysis and Characterization, Peptides More...
InChI Key   XPDXVDYUQZHFPV-UHFFFAOYSA-N
product line   BioReagent
assay   ≥99% (HPLC)
form   powder and chunks
color   yellow to yellow-orange
mp   72-74 °C (lit.)
solubility   acetone: 20 mg/mL
suitability   suitable for amino acid labeling
storage temp.   −20°C

Description

Application

Dansyl chloride has been used:
• as a fluorogenic reagent for fluorescent N-terminal derivatization of amino acids and peptides and detection by reverse phase high performance liquid chromatography (HPLC)
• in the derivatization of plasma samples
• in the quantification of immobilized alkaline phosphatase

A fluorogenic reagent for fluorescent N-terminal derivatization of amino acids and peptides and detection by reverse phase HPLC.

Packaging

1, 5, 25 g in glass bottle

Biochem/physiol Actions

Dansyl chloride is a sulfonyl chloride compound. It is used to end tag amino groups of peptides and proteins. Dansyl chloride is used for derivatization of free amino acids and amines in neural samples and biological fluids. It is used to study fluorescent conjugates of albumin, protein conformational changes studies and active site characterization.

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3261 8 / PGII
WGK Germany 
3
RTECS 
QK3688000

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles
Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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