D3695 Sigma-Aldrich


≥98% (HPLC)

Synonym: Dimethyloxalylglycine, N-(Methoxyoxoacetyl)-glycine methyl ester

  • CAS Number 89464-63-1

  • Empirical Formula (Hill Notation) C6H9NO5

  • Molecular Weight 175.14

  •  MDL number MFCD05865098

  •  PubChem Substance ID 329798774

  •  NACRES NA.77




DMOG has been used:
• in hypoxia-inducible factor (HIF) activity assay
• to examine its effects on the degradation of HIF-1α and renal regeneration
• in DMOG preconditioning of adipose tissues
• as vehicle control for the primary liquid culture of CD34+ cells
• for endothelial cell stimulation

Dimethyloxalylglycine (DMOG) has been used as an inhibitor of ten-eleven translocation 3 (TET3) protein.


10, 50 mg in glass bottle

Biochem/physiol Actions

DMOG is a cell permeable prolyl-4-hydroxylase inhibitor, which upregulates HIF (hypoxia-inducible factor). The protein level of HIF-1α subunit is post-transcriptionally regulated by prolyl and asparaginyl hydroxylase (PAH). Suppression of PAH activity increases endogenous HIF-1α levels. DMOG is a cell permeable, competitive inhibitor of prolyl hydroxylase domain-containing proteins (PHDs and HIF-PHs). It has been discovered that the DMOG posseses neuroprotective effect on NFG deprived cell cultures through preservation of glucose metabolism. DMOG also attenuates myocardial injury in a rabbit ischemia reperfusion model. DMOG is more potent than the older inhibitor 4-Phenyl-pyridine-2,5-dicarboxylic acid (R395889; Sigma-Aldrich rare chemicals library). The IC50 is 5.18 μM.

Features and Benefits

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Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
Precautionary statements 
NONH for all modes of transport
WGK Germany 


Certificate of Analysis (COA)

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Protocols & Articles


Discover Bioactive Small Molecules for Gene Regulation

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Peer-Reviewed Papers


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