• USA Home
  • D3900 - Desipramine hydrochloride

EMAIL THIS PAGE TO A FRIEND
D3900 Sigma-Aldrich

Desipramine hydrochloride

≥98% (TLC), powder

  • CAS Number 58-28-6

  • Empirical Formula (Hill Notation) C18H22N2 · HCl

  • Molecular Weight 302.84

  •  EC Number 200-373-1

  •  MDL number MFCD00058108

  •  PubChem Substance ID 24278094

  •  NACRES NA.77

Purchase

Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Biogenic Amine Transport Inhibitors,
assay   ≥98% (TLC)
form   powder
color   white to off-white
solubility   H2O: 50 mg/mL
originator   Sanofi Aventis
storage temp.   2-8°C
SMILES string   Cl[H].CNCCCN1c2ccccc2CCc3ccccc13
InChI   1S/C18H22N2.ClH/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20;/h2-5,7-10,19H,6,11-14H2,1H3;1H
InChI key   XAEWZDYWZHIUCT-UHFFFAOYSA-N

Description

General description

Desipramine, a metabolite of imipramine and iofepramine is an active tricyclic antidepressant.

Application

Desipramine hydrochloride has been used:
• to prevent norepinephrine neuron degeneration and to maximize uptake into DA neurons
• to protect unselective damage to the noradrenergic system
• as a norepinephrine re-uptake inhibitor to treat rats for lesioning

Packaging

1, 5, 25 g in glass bottle

Biochem/physiol Actions

Desipramine is used to treat depression. It is also used to manage enuresis in children. Desipramine helps to eliminate the pain triggered by diabetic neuropathy.

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (Ki = 4 nM) than the serotonin transporter (Ki = 61 nM).

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Caution

Hygroscopic

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
HO0525000
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?