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D4000 Sigma-Aldrich

trans-Dehydroandrosterone

≥99%

Synonym: 3β-Hydroxy-5-androsten-17-one, 5-Androsten-3β-ol-17-one, DHEA, Dehydroepiandrosterone, Dehydroisoandrosterone, Prasterone

  • CAS Number 53-43-0

  • Empirical Formula (Hill Notation) C19H28O2

  • Molecular Weight 288.42

  •  Beilstein/REAXYS Number 2058110

  •  EC Number 200-175-5

  •  MDL number MFCD00003613

  •  PubChem Substance ID 24278369

  •  NACRES NA.77

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Properties

Related Categories Androgen, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones,
Quality Level   200
biological source   synthetic (organic)
assay   ≥99%
form   crystalline powder
drug control   Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada
mp   149-151 °C (lit.)
solubility   chloroform: 50 mg/mL, clear, colorless
shipped in   ambient
storage temp.   room temp
SMILES string   C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@]34C)[C@@H]1CCC2=O
InChI   1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1
InChI key   FMGSKLZLMKYGDP-USOAJAOKSA-N
Gene Information   human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), SERPINA6(866)
rat ... Ar(24208)

Description

Packaging

10, 25, 100, 250 g in poly bottle

Biochem/physiol Actions

Dehydroandrosterone (DHEA) is a negative modulator of GABAA receptors. It is a steroid secreted by the adrenal gland with both estrogenic and androgenic properties. DHEAs conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors.

Negative modulator of GABAA receptors. Steroid secreted by the adrenal gland with both estrogenic and androgenic properties. Its conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors. At high but physiologically valid concentrations, DHEA inhibits proliferation of chromaffin progenitor cells and induces dopaminergic differentiation.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Personal Protective Equipment 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
WGK 2
RTECS 
BV8396000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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