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D4434 Sigma-Aldrich

Dichloromethylenediphosphonic acid disodium salt

Synonym: Cl2MDP, Clodronate disodium, Clodronic acid disodium salt, DMDP

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Properties

Related Categories A to C, Anti-Proliferative Agents, Antitumor Agents, Application Index, Bioactive Small Molecule Alphabetical Index,
Quality Level   300
form   powder
solubility   water: 49.00-51.00 mg/mL, clear, colorless
storage temp.   room temp
SMILES string   [Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O
InChI   1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
InChI key   HJKBJIYDJLVSAO-UHFFFAOYSA-L
Gene Information   rat ... Man2a1(25478), Si(497756)

Description

Packaging

1 g in glass bottle

Biochem/physiol Actions

Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma. When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver. Found also to inhibit collagenase and matrix metalloproteinase1.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
SZ7640700
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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