• USA Home
  • D4626 - Dextran from Leuconostoc mesenteroides

D4626 Sigma-Aldrich

Dextran from Leuconostoc mesenteroides

average mol wt 15,000-30,000



Quality Level   200
biological source   bacterial (Leuconostoc mesenteroides)
form   powder
optical activity   [α]/D 199°
mol wt   average mol wt 15,000-30,000


General description

Dextran is a branched glucan composed of linear α(1→6) linked glucose units and α (1→3) link initiated branches. Dextran ranges in size from 10,000 to 150,000 kDa.


Dextrans are used in many applications as volume extenders, osmotic pressure regulators, stabilizers, matrix components, copolymers, microcarriers, binding agents, viscosity modifiers, antithrombotics, lubricants and physical structure components. Dextrans may be used as long hydrophilic spacer arms to improve the performance (freedom of movement) of conjugated/bound proteins. Dextrans may be derivatized for use in biosensor systems. Dextrans of less than 60,000 kDa are generally considered low molecular weight dextrans. Low molecular weight dextrans are often preferred versus high molecular weight dextrans due to their viscosities, aggregation and permeation properties. High molecular weight, water-soluble, dextran polymers have been used in a wide variety of biomedical applications. Dextran (15,000-30,000), a low molecular weight dextran, may be used to study processes such as transient plasma membrane permeabilization. Dextran (15,000-30,000), may be used as a sugar based crowding agent in protein packing and folding studies.

Use of dextrans as long and hydrophilic spacer arms improves the performance of immobilized proteins acting on macromolecules.


1 kg in poly drum

Preparation Note

With the exception of the highest MW dextran, D5501 (MW range = 5 million to 40 million), dextrans are very water soluble. Sigma tests the solubility of dextrans at concentrations generally exceeding 30 mg/ml in water. Dextrans are also freely soluble in DMSO, formamide, ethylene glycol, and glycerol. Neutral-aqueous dextran solutions can be sterilized by autoclaving at 110-115oC for 30 to 45 minutes. Dextran can be hydrolyzed by strong acids at high temperatures. The terminal reducing end group of dextran can be oxidized in alkaline solutions.

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

Please Enter a Lot Number
Protocols & Articles


Applications of Glucose Polymers in the Synthesis of Diagnostic and Drug Delivery Nanoparticles

Colorado Center for Nanomedicine and Nanosafety, Translational Bio-Nanosciences Laboratory, Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of...
Keywords: Absorption, Agriculture, Biomaterials, Building blocks, Cancer, Chromatography, Clinical, Column chromatography, Degradations, Diagnostic, Dialysis, Environmental, High performance liquid chromatography, Inflammation, Ligands, Magnetic resonance imaging, Nucleic acid hybridization, Oxidations, PEGylations, Pharmaceutical, Polymerization reactions, Positron Emission Tomography, Purification, Reductions



Dextran is a polymer of anhydroglucose.  It is composed of approximately 95% alpha-D-(1-6) linkages. The remaining a(1-3) linkages account for the branching of dextran.1,2,3 Conflicting data on the b...
Keywords: Centrifugation, Diffusion, Fractionation, Immunoelectrophoresis, Precipitation, Separation

Peer-Reviewed Papers


Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?