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  • D5193 - 17-Dimethylaminoethylamino-17-demethoxygeldanamycin

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D5193 Sigma-Aldrich

17-Dimethylaminoethylamino-17-demethoxygeldanamycin

Synonym: 17-DMAG

  • Empirical Formula (Hill Notation) C32H48N4O8

  • Molecular Weight 616.75

  •  NACRES NA.85

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Properties

Related Categories Antibiotics, Benzenoids, Biochemicals and Reagents, Chemical Structure Class
Quality Level   100
biological source   synthetic
form   powder
color   purple
solubility   ethanol: ~10 mg/mL (lit.)
  DMSO: >25 mg/mL (lit.)
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   neoplastics
storage temp.   −20°C

Description

General description

Chemical structure: benzenoid

Application

17-DMAG has been used to block the NF-κB inflammatory cascade in the murine model. It a potential therapeutic agent for non-small-cell lung cancers (NSCLC).

Biochem/physiol Actions

17-DMAG is a heat shock protein (HSP90) inhibitor. 17-DMAG is a more potent analog of geldanamycin. It inhibits cancer growth and promotes apoptosis in multiple cell lines. 17-DMAG is a more potent antitumor agent than 17-AAG.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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