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D5294 Sigma-Aldrich

Dilazep dihydrochloride

powder

Synonym: ASTA C 4898, Cormelian, N,N′-bis(3-[3,4,5-Trimethoxybenzoyloxy]propyl)homopiperazine dihydrochloride

  • CAS Number 20153-98-4

  • Empirical Formula (Hill Notation) C31H44N2O10 · 2HCl

  • Molecular Weight 677.61

  •  EC Number 243-548-8

  •  MDL number MFCD00133267

  •  PubChem Substance ID 24278372

  •  NACRES NA.77

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Properties

Related Categories Adenosines/P2 Nucleotide Receptors (Purinergics), Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   200
form   powder
color   white
solubility   H2O: 10 mg/mL
storage temp.   2-8°C
SMILES string   Cl[H].Cl[H].COc1cc(cc(OC)c1OC)C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2
InChI   1S/C31H44N2O10.2ClH/c1-36-24-18-22(19-25(37-2)28(24)40-5)30(34)42-16-8-12-32-10-7-11-33(15-14-32)13-9-17-43-31(35)23-20-26(38-3)29(41-6)27(21-23)39-4;;/h18-21H,7-17H2,1-6H3;2*1H
InChI key   VILIWRRWAWKXRW-UHFFFAOYSA-N
Gene Information   human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)

Description

General description

Dilazep comprises central cyclic diamine and phenyl rings connected via alkyl linkers.

Application

Dilazep dihydrochloride has been used in estrogen receptor (ERα) antagonistic assay. It has also been used as an equilibrative nucleoside transporter inhibitor (ENT 1 and 2) in cancer cell lines.

Packaging

100 mg in glass bottle

50 mg in poly bottle

Biochem/physiol Actions

Dilazep is a equilibrative nucleoside transporter 1 (ENTs) inhibitor. It is an antianginal drug and an effective coronary vasodilator. Dilazep elicits anti-albuminuric effects and is an anti-platelet agent. It is a potent adenosine uptake inhibitor and suppresses effects of ischemia.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
RTECS 
DI0250000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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