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D5314 Sigma-Aldrich

DPQ

≥98% (HPLC), solid

Synonym: 3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone

  • CAS Number 129075-73-6

  • Empirical Formula (Hill Notation) C18H26N2O2

  • Molecular Weight 302.41

  •  MDL number MFCD01866274

  •  NACRES NA.77

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Properties

Related Categories Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
Quality Level   200
biological source   synthetic (organic)
assay   ≥98% (HPLC)
form   solid
mp   107-109  °C
solubility   DMSO: 1 mg/mL, clear, colorless to faintly yellow
storage temp.   2-8°C

Description

Application

DPQ has been used as a PARP1 (poly(ADP-ribose) polymerase 1) inhibitor in in vivo studies to determine the loss of γ-H2AX (H2A histone family member X) upon irradiation.

Biochem/physiol Actions

3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) is known to decrease the PARP 1 (poly(ADP-ribose) polymerase 1) mediated apoptosis under the influence of ischemia. It is considered as more effective inhibitor than the traditionally used PARP1 inhibitor 3-aminobenzamide.

DPQ is a very potent poly(ADP-ribose) polymerase (PARP) inhibitor.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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