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D5321 Sigma-Aldrich

D36 hydrate

≥98% (HPLC)

Synonym: 5-(2-methoxyphenyl)-1-(2-methylpropyl)-1H-Indole-3-acetamide Hydrate

  • Empirical Formula (Hill Notation) C21H24N2O2 · xH2O

  • Molecular Weight 336.43 (anhydrous basis)

  •  MDL number MFCD16875421

  •  PubChem Substance ID 329798803

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Properties

Related Categories Androgen, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to off-white
solubility   DMSO: >10 mg/mL
originator   GlaxoSmithKline
storage temp.   2-8°C
SMILES string   O.COc1ccccc1-c2ccc3n(CC(C)C)cc(CC(N)=O)c3c2
InChI   1S/C21H24N2O2.H2O/c1-14(2)12-23-13-16(11-21(22)24)18-10-15(8-9-19(18)23)17-6-4-5-7-20(17)25-3;/h4-10,13-14H,11-12H2,1-3H3,(H2,22,24);1H2
InChI key   ZERKAKHVUQMJPW-UHFFFAOYSA-N

Description

Packaging

5 mg in glass bottle

Biochem/physiol Actions

D36 is an androgen receptor (AR) allosteric antagonist with inverse agonist properties. D36 inhibits both wild-type and agonist-induced AR activity and antagonized AR in a hormone-refractory model.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Nuclear Receptors (Steroids)

Intracellular receptors (IRs) are a class of ligand-dependent transcription factors that include receptors for both steroid and non-steroid hormones. Upon binding their cognate hormone, these recepto...
Keywords: Anti-inflammatory agents, Apoptosis, Atomic absorption spectroscopy, Cancer, Cardiovascular, Cell proliferation, Diseases, Diuretics, Gene expression, Hormones, Infrared spectroscopy, Ligands, Metabolism, Metabolites, Transcription, Transduction

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