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  • D5943 - 2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide

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D5943 Sigma-Aldrich

2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide

≥98% (HPLC), solid

Synonym: Flt-3 inhibitor

  • CAS Number 301305-73-7

  • Empirical Formula (Hill Notation) C18H20N2O4S

  • Molecular Weight 360.43

  •  MDL number MFCD00617269

  •  PubChem Substance ID 24724465

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DIG-DY,
Quality Level   100
assay   ≥98% (HPLC)
form   solid
storage condition   protect from light
  under inert gas
color   white to off-white
solubility   H2O: <2 mg/mL
  DMSO: ~8 mg/mL
storage temp.   −20°C
SMILES string   COc1ccc(cc1OC)C(=O)Nc2sc3CCCCc3c2C(N)=O
InChI   1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)
InChI key   FSPQCTGGIANIJZ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Flt-3 (fms-related tyrosine kinase 3) inhibitor

Features and Benefits

This compound is featured on the PDGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

PDGFR

Platelet-derived growth factor (PDGF) is a family of disulfide-bonded dimeric molecules of A-, B-, C- and D-polypeptide chains (PDGF-AA, -AB, -BB, -CC and -DD). PDGF isoforms stimulate proliferation,...
Keywords: Atomic absorption spectroscopy, Cell proliferation, Central Nervous System, Diseases, Gastrointestinal, Growth factors, Ligands, Phosphorylations, Solid state metathesis, Transcription, transformation

Peer-Reviewed Papers
15

References

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