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D6446 Sigma-Aldrich

DOV 216,303

≥98% (HPLC)

Synonym: (±)-1-(3,4-dichlorophenyl)-3-azabicyclo-[3.1.0]hexane hydrochloride

  • CAS Number 86215-36-3

  • Empirical Formula (Hill Notation) C11H11Cl2N · HCl

  • Molecular Weight 264.58

  •  MDL number MFCD06407666

  •  PubChem Substance ID 329798827

  •  NACRES NA.77

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, DIG-DY,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: ≥10 mg/mL
originator   Merck & Co., Inc., Kenilworth, NJ, U.S.
storage temp.   −20°C
SMILES string   Cl.Clc1ccc(cc1Cl)C23CNCC2C3
InChI   1S/C11H11Cl2N.ClH/c12-9-2-1-7(3-10(9)13)11-4-8(11)5-14-6-11;/h1-3,8,14H,4-6H2;1H
InChI key   KAGBHVBIOJBGBD-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Triple reuptake inhibitor (TRI); serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI); IC50 values of ~20, 14, and 78 nM, respectively.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Dopamine Receptors

Dopamine receptors were initially differentiated into two major types based on the ability of dopamine to stimulate (D1) or inhibit (D2) adenylyl cyclase activity and produce the second-messenger mol...
Keywords: Atomic absorption spectroscopy, Dopamine agents, Gene expression, Genetic, Genetics, Ligands, Methylations, Parkinson Disease, Schizophrenia, Transduction

Serotonin Receptors

Serotonin (5-hydroxytryptamine, 5-HT) is widely distributed throughout the mammalian body, being synthesized from L-tryptophan in enterochromaffin cells of the gastro-intestinal tract as well as in s...
Keywords: Active transport, Atomic absorption spectroscopy, Cancer, Clinical, Gene expression, Ligands, Neurotransmitters, Obesity, Polymorphisms, Schizophrenia, Transduction

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