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D6696 Sigma-Aldrich

Doramectin synthetic

Synonym: 25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin, Doramectin

  • CAS Number 117704-25-3

  • Empirical Formula (Hill Notation) C50H74O14

  • Molecular Weight 899.11

  •  MDL number MFCD00894747

  •  PubChem Substance ID 329798834

  •  NACRES NA.85

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Properties

Quality Level   200
biological source   synthetic
assay   ≥90%
form   solid
impurities   ≤5% water (Karl Fischer)
color   white
solubility   methanol: soluble
Mode of action   cell membrane | interferes
antibiotic activity spectrum   parasites
storage temp.   −20°C
SMILES string   [H][C@@]12OC/C3=C\C=C\[C@H](C)[C@H](O[C@@H]4C[C@H](OC)[C@@H](O[C@@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)\C(C)=C\CC6C[C@@H](C[C@]7(O6)O[C@@H]([C@@H](C)C=C7)C8CCCCC8)OC(=O)[C@H](C=C(C)[C@H]1O)[C@@]23O
InChI   1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16+/t27-,29-,31-,32-,35?,36-,37-,38-,39-,40+,41+,42+,43-,44-,45-,46-,47+,49+,50+/m0/s1
InChI key   QLFZZSKTJWDQOS-TTXKVKCHSA-N

Description

Application

Doramectin is commonly used in veterinary medicine for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites. It is effective against Haemonchus spp., Ostertagia spp., Trichostrongylus spp., Cooperia spp., Oesophagostomum spp., Dyctiocaulus viviparus, Dermatobia hominis, Boophilus microplus, Psoroptes bovis, as well as other internal and external parasites.

Packaging

100 mg in poly bottle

Biochem/physiol Actions

Doramectin is a derivative of ivermectin. It is thought to work like other macrocyclic lactones by opening glutamate-gated chloride channels in the nerve cells, causing paralysis.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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