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D6946 Sigma-Aldrich

(R)-DRF053 hydrochloride hydrate

≥98% (HPLC)

Synonym: 2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]- 9H-purin-2-yl]amino]-1-butanol hydrochloride hydrate

  • Empirical Formula (Hill Notation) C23H27N7O · xHCl · yH2O

  • Molecular Weight 417.51 (anhydrous free base basis)

  •  MDL number MFCD17215921

  •  PubChem Substance ID 329798839

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, DIG-DY
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   yellow
solubility   DMSO: ≥30 mg/mL
storage temp.   2-8°C
SMILES string   O.Cl.CC[C@H](CO)Nc1nc(Nc2cccc(c2)-c3ccccn3)c4ncn(C(C)C)c4n1
InChI   1S/C23H27N7O.ClH.H2O/c1-4-17(13-31)27-23-28-21(20-22(29-23)30(14-25-20)15(2)3)26-18-9-7-8-16(12-18)19-10-5-6-11-24-19;;/h5-12,14-15,17,31H,4,13H2,1-3H3,(H2,26,27,28,29);1H;1H2/t17-;;/m1../s1
InChI key   ZOSNTFVWVJFXQO-ZEECNFPPSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

DRF053 is a more potent version of roscovitine. It is 2 fold more potent against CDK5 (80 nM) and over 150 times more potent against CDK1 (14 nM).

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

CDKs

Cyclin dependent kinases (CDKs) are typical serine/threonine kinases that display the 11 subdomains shared by all kinases. The complete sequence of the Homo sapiens genome shows that among the ~30,00...
Keywords: Alzheimer Disease, Apoptosis, Atomic absorption spectroscopy, Cancer, Cardiovascular, Catalysis, DNA replication, Diseases, Gene expression, Parkinson Disease, Phosphorylations, Transcription

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