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D7385 Sigma-Aldrich

Demecolcine

≥98% (HPLC)

Synonym: N-Deacetyl-N-methylcolchicine

  • CAS Number 477-30-5

  • Empirical Formula (Hill Notation) C21H25NO5

  • Molecular Weight 371.43

  •  Beilstein/REAXYS Number 2822892

  •  EC Number 207-514-6

  •  MDL number MFCD00075459

  •  PubChem Substance ID 24894128

  •  NACRES NA.47

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Properties

Related Categories Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, Inhibitors,
Quality Level   200
assay   ≥98% (HPLC)
form   powder
application(s)   hematology: suitable
  histology: suitable
mp   184 °C
solubility   chloroform: 10 mg/mL
  ethanol: soluble
Featured Industry   Diagnostic Assay Manufacturing
storage temp.   2-8°C
SMILES string   CN[C@H]1CCc2cc(OC)c(OC)c(OC)c2C3=CC=C(OC)C(=O)C=C13
InChI   1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1
InChI key   NNJPGOLRFBJNIW-HNNXBMFYSA-N

Description

Application

Demecolcine has been used as a microtubule depolymerizing agent. It has also been used to inhibit mitotic division.

Biochem/physiol Actions

Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
WGK 3
RTECS 
GH0800000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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