D7693 Sigma

Dynasore hydrate

Synonym: 3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide hydrate

  • CAS Number 1202867-00-2

  • Empirical Formula (Hill Notation) C18H14N2O4 · xH2O

  • Molecular Weight 322.31 (anhydrous basis)

  •  MDL number MFCD11045288

  •  PubChem Substance ID 329798784



Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DIG-DY,
form   powder
storage condition   protect from light
color   off-white
solubility   DMSO: ≥10 mg/mL
  H2O: insoluble
storage temp.   −20°C


Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Biochem/physiol Actions

Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.

General description

Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.


5, 25 mg in glass bottle

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Safety & Documentation

Safety Information

GHS09  GHS09
Signal word 
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
UN 3077 9 / PGIII
WGK Germany 


Certificate of Analysis

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option:
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
How can I store a solution of Product D7693, Dynasore hydrate?
We do not test solution stability for this product. In general, drug solutions are best prepared immediately before use.  We recommend storing at -20°C in single use aliquots.
What can I use to make a solution of Product D7693, Dynasore hydrate?
As listed on the product page on the website, Dynasore is soluble in DMSO at 10 mg/mL.  It is also soluble in ethanol at 1 mg/mL.  
What concentration of Product D7693, Dynasore hydrate, should I use in my experiment?
The following reference uses Dynasore at 80 μM:  Massol, R.H., et al., A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating.  Proc. Nat. Acad. Sci., USA, 103, 10265-10270 (2006).
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
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