D7693 Sigma-Aldrich

Dynasore hydrate

Synonym: 3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide hydrate

  • CAS Number 1202867-00-2

  • Empirical Formula (Hill Notation) C18H14N2O4 · xH2O

  • Molecular Weight 322.31 (anhydrous basis)

  •  MDL number MFCD11045288

  •  PubChem Substance ID 329798784

  •  NACRES NA.77



Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DIG-DY,
Quality Level   100
form   powder
storage condition   protect from light
color   off-white
solubility   DMSO: ≥10 mg/mL
  H2O: insoluble
storage temp.   −20°C
SMILES string   O.Oc1ccc(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O
InChI   1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;


General description

Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.


Dynasore hydrate has been used:
• for priming fetal mesenchymal stem/stromal cells (fMSC)
• in confocal microscopy
• in wound healing/scratch and tube-formation assay
• to analyse its effects on Coxsackievirus A9 (CAV9) infection
• to inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosis
• in live imaging of cells


5, 25 mg in glass bottle

Biochem/physiol Actions

Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at

Safety & Documentation

Safety Information

GHS09  GHS09
Signal word 
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
UN 3077 9 / PGIII
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
How can I store a solution of Product D7693, Dynasore hydrate?
We do not test solution stability for this product. In general, drug solutions are best prepared immediately before use.We recommend storing at -20°C in single use aliquots.
What can I use to make a solution of Product D7693, Dynasore hydrate?
As listed on the product page on the website, Dynasore is soluble in DMSO at 10 mg/mL.It is also soluble in ethanol at 1 mg/mL.
What concentration ofProduct D7693, Dynasore hydrate, should I use in my experiment?
The following reference uses Dynasore at 80 μM:Massol, R.H., et al., A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating.Proc. Nat. Acad. Sci., USA, 103, 10265-10270 (2006).
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