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D7802 Sigma-Aldrich

Daidzein

≥98%, synthetic

Synonym: 4′,7-Dihydroxy­iso­flavone, 7-Hydroxy-3-(4-hydroxy­phenyl)-4H-1-benzo­pyran-4-one, 7-Hydroxy-3-(4-hydroxy­phenyl)­chromone, Isoaurostatin

  • CAS Number 486-66-8

  • Empirical Formula (Hill Notation) C15H10O4

  • Molecular Weight 254.24

  •  Beilstein/REAXYS Number 231523

  •  EC Number 207-635-4

  •  MDL number MFCD00016954

  •  PubChem Substance ID 24278030

  •  NACRES NA.77

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Properties

Related Categories Apoptosis and Cell Cycle, Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Cycle Proteins, Antibodies and Reagents,
Quality Level   200
biological source   synthetic
InChI Key   ZQSIJRDFPHDXIC-UHFFFAOYSA-N
assay   ≥98%
solubility   DMSO: 10 mg/mL
storage temp.   −20°C
Gene Information   human ... ESR1(2099), ESR2(2100), UGT1A4(54657)
mouse ... Aldh1a2(19378), Hexa(15211), Maoa(17161)
rat ... Aldh1a2(116676)

Description

General description

Daidzein is an isoflavone present in soy. It regulates oxidative stress, angiogenesis, cell growth and apoptosis. Daidzein has antioxidant, antiestrogenic and antiatherogenic properties. It provides protection against osteoporosis.

Application

Daidzein has been used:
• as a control to evaluate fertility in rats
• to study its effects on ovarian cancer
• to simulate in vitro antioxidant activity

Packaging

100 mg in glass bottle

25 mg in poly bottle

Packaged under Argon.

Biochem/physiol Actions

Soy isoflavone daidzein protects against oxidative damage in liver cells induced by 7,12-dimethylbenz[a]anthracene (DMBA). Catalase and superoxide dismutase activity, down-regulated by DMBA, was restored by daidzein.

Daidzein is a phytoestrogen that is suggested to play a role in preventing hormone-induced cancers. Arrests cell cycle at G1 in Swiss 3T3 cells.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
DJ3100040

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
Biofiles Volume 2 Article 2
Keywords: Adhesion, Anti-inflammatory agents, Applications, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

LC/MS Analysis of Isoflavones on Chromolith® FastGradient RP-18 endcapped

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Isoflavones on Chromolith® FastGradient RP-18 endcapped
Keywords: Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry

Peer-Reviewed Papers
15

References

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