D8696 Sigma


>99.0% (HPLC)



Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
assay   >99.0% (HPLC)
form   powder
storage condition   desiccated
color   off-white to brown
solubility   DMSO: 20 mg/mL
originator   Merck & Co., Inc., Kenilworth, NJ
storage temp.   2-8°C



5, 25 mg in glass bottle

Biochem/physiol Actions

DMH4 is a potent VEGF inhibitor and an angiogenesis inhbitor. It is a selective VEGF inhibitor with an IC50 of 161 nM for VEGFR inhibition compared to 8000 nM for AMPK. Unlike the structurally similar DMH1, which is a selective BMP inhibitor, DMH4 shows little affinitiy for BMP with an IC50 of 3500 nM for BMPR-I.

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Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Protocols & Articles


Discover Bioactive Small Molecules for Cytokines & Growth Factors Research

Cytokines and growth factors (GF) are chemical messengers that mediate intracellular communication, thereby regulating cellular and nuclear functions. These chemical messengers bind cell surface rece...
Keywords: Biological processes, Cancer, Cell proliferation, Diseases, Growth factors, Ligands, Phosphorylations, Transcription, Transduction

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Phosphorylation is a ubiquitous cellular regulatory mechanism that mediates signal transduction pathways, which carry signals from the cell surface to the nucleus or cytoplasm, by altering the activi...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Diseases, Inflammation, Metabolism, Neurodegenerative Diseases, Phosphorylations, Transduction


The vascular endothelial growth factor receptor (VEGFR) family comprises in humans three endothelial cell (EC) specific tyrosine kinase receptors (VEGFR-1, VEGFR-2 and VEGFR-3). VEGFRs are the major ...
Keywords: Angiogenesis, Atomic absorption spectroscopy, Capillary electrophoresis, Cardiovascular, Growth factors, Ligands, Phosphorylations

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