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D9150 Sigma-Aldrich

2,3-Dimethoxy-5-methyl-p-benzoquinone

apoptosis inducer

Synonym: Coenzyme Q0

  • CAS Number 605-94-7

  • Empirical Formula (Hill Notation) C9H10O4

  • Molecular Weight 182.17

  •  Beilstein/REAXYS Number 1640422

  •  EC Number 210-100-8

  •  MDL number MFCD00001595

  •  PubChem Substance ID 24894261

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Properties

Related Categories Biochemicals and Reagents, Coenzymes, Nucleosides, Nucleotides, Oligonucleotides More...
mp   58-60 °C (lit.)
storage temp.   2-8°C
SMILES string   COC1=C(OC)C(=O)C(C)=CC1=O
InChI   1S/C9H10O4/c1-5-4-6(10)8(12-2)9(13-3)7(5)11/h4H,1-3H3
InChI key   UIXPTCZPFCVOQF-UHFFFAOYSA-N

Description

General description

2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q0 or DMM) is present in all the cells including neural cells.

Application

2,3-Dimethoxy-5-methyl-p-benzoquinone has been used:
• as a tau protein fibrillization inducer to determine the regions of tau involved in the formation of paired helical filaments (PHFs)
• as a component in buffer B for cytochrome oxidation assay with subsaturating light
• in the RPMI-1640 medium for 2,3-bis-(2-methoxy-4-nitro-5-sulphenyl)-(2H)-tetrazolium-5-carboxanilide (XTT) assay to quantify antifungal activity

Coenzyme Q0 inhibits (via radical quenching) reactions of gamma-irradiation induced homolytic cleavage of O-glycoside bonds in polysaccharides. Coenzyme Q0 induces apoptosis and modulates the cell cycle in estrogen receptor negative breast cancer cells. It is toxic to other cells such as insulin producing cells.

Packaging

1, 5 g in glass bottle

Biochem/physiol Actions

2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q0) interacts with tau protein and aids in the formation of filamentous structure.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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