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D9439 Sigma-Aldrich

Desmosine chloride

from bovine, 99.5%±0.2%

  • CAS Number 10019-68-8

  • Empirical Formula (Hill Notation) C24H40ClN5O8

  • Molecular Weight 562.06

  •  MDL number MFCD12910449

  •  PubChem Substance ID 329798901

  •  NACRES NA.56

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Properties

Related Categories Auxiliary Proteins, Biochemicals and Reagents, Other, Proteins and Derivatives
Quality Level   100
biological source   bovine
InChI Key   FUPMLZCXPJSGPV-UHFFFAOYSA-N
assay   99.5%±0.2%
purified by   chromatography (and purified by solvent extraction)
storage temp.   2-8°C

Description

General description

Each vial contains 1 μmole of purified desmosine.

Application

Desmosine chloride is often used in assays for free or urinary desmosine as markers for disease states characterized by elastin degradation (e.g., emphysema). Elastin degradation has shown strong correlation with vascular calcification, and pretreatment with aluminum ions can inhibit the binding of matrix metalloproteinase (MMP) to elastin.

Assays for free or urinary desmosine are often used as markers for disease states characterized by elastin degradation (e.g., emphysema). Conversely, excessive levels of incorporated desmosine are indicators of fibrotic conditions (e.g., cirrhosis).

Biochem/physiol Actions

Desmosine is a polyfunctional amino acid that forms cross-links in mature elastin.

Caution

Extremely hygroscopic

Analysis Note

Calibrated by UV and amino acid analysis.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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