EMAIL THIS PAGE TO A FRIEND
D9446 Sigma-Aldrich

L-DOPS

≥98% (HPLC)

Synonym: Droxidopa, L-threo 3,4-Dihydroxyphenylserine

  • CAS Number 23651-95-8

  • Empirical Formula (Hill Notation) C9H11NO5

  • Molecular Weight 213.19

  •  MDL number MFCD00799030

  •  PubChem Substance ID 329798902

  •  NACRES NA.77

Purchase

Properties

Related Categories Adrenergics, Agonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to tan
solubility   DMSO: ≥3 mg/mL
storage temp.   −20°C
SMILES string   N[C@@H]([C@H](O)c1ccc(O)c(O)c1)C(O)=O
InChI   1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1
InChI key   QXWYKJLNLSIPIN-JGVFFNPUSA-N
Gene Information   human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155)

Description

General description

L-DOPS, also called L-threo 3,4-Dihydroxyphenylserine or droxidopa is a catecholamine. L-DOPS has many clinical advantages and may be useful for treating norepinephrine deficiency. It is used for treating neurogenic orthostatic hypotension and improves norepinephrine levels. L-DOPS mediates reduction of amyloid plaques and could have a therapeutic potential for treating amyloid pathology.

Application

L-DOPS has been administered for clinical trial studies in mice with amyloid pathology.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

L-DOPS is a norepinephrine precursor in vivo.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Dopamine, Norepinephrine and Epinephrine Synthesis page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

Assay and Organic Impurity Profiling of Droxidopa using a ZIC-HILIC column and UV detection

Droxidopa is a synthetic amino acid precursor, and acts as a prodrug to norepinephrine (noradrenaline) to increase neurotransmitter concentration in the body and the brain. Droxidopa was developed by...
Keywords: High performance liquid chromatography, Neurotransmitters, Pharmaceutical

Dopamine, Norepinephrine and Ephinephrine Synthesis

Phenylalanine is an essential amino acid that is converted to tyrosine primarily in the liver by phenylalanine hydroxylase. Blood borne tyrosine, derived from dietary proteins and from phenylalanine ...
Keywords: Catalysis, Enzyme activity, Hydroxylations, Metabolism, Phosphorylations

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?