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  • E0377 - D-Erythrose 4-phosphate sodium salt

E0377 Sigma-Aldrich

D-Erythrose 4-phosphate sodium salt

Synonym: 4-Phospho-D-erythrose sodium salt

  • CAS Number 103302-15-4

  • Empirical Formula (Hill Notation) C4H8NaO7P

  • Molecular Weight 222.07



Related Categories Biochemicals and Reagents, Carbohydrates, Carbohydrates A to Z, Carbohydrates D-F, Monosaccharide More...
storage temp.   −20°C



D-Erythrose 4-phosphate (E4P) is used as a substrate to identify, differentiate and characterize 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) aldolase(s) and 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAH7P) synthase(s) that initiate the shikimate pathway in microorganisms and plants. It may be used as a substrate to identify, differentiate and characterize glyceraldehyde-3-phosphate dehydrogenase(s) (GAPDH) involved in surface antigen and virulence factor development in pathogenic microorganisms. E4P may be used in malaria research as an inhibitor of the PfPdx1 component of the PLP (pyridoxal 5′-phosphate) synthase enzymatic complex responsible for the de novo synthesizes vitamin B6 in Plasmodium falciparum.


10 mg in autosample vial

Biochem/physiol Actions

Erythrose 4-phosphate is an intermediate in the penntose phosphate pathway, as well as the biosynthesis of phenylalanine, tyrosine, tryptophan and metabolism of vitamin B6.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. E0377.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


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Protocols & Articles


Calvin Cycle

The Calvin cycle is a more complex process used by algae, plants and photosynthetic bacteria to convert carbon dioxide and water into carbohydrate and molecular oxygen with the aid of sunlight. The l...
BioFiles 2007, 2.6, 27.
Keywords: Aldol condensation, Biofiles, Catalysis, Condensations, Isomerizations, Phosphorylations, Reductions

Pentose Phosphate Pathway

While glucose metabolism by glycolysis occurs where energy is needed quickly, e.g. in brain and muscle cells, a second pathway for glucose metabolism, called pentose phosphate pathway, operates in ti...
BioFiles 2007, 2.6, 25.
Keywords: Catalysis, Glycolysis, Metabolism, Oxidations, Pentose phosphate pathway

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