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E1257 Sigma-Aldrich

Epidermal Growth Factor from murine submaxillary gland

lyophilized powder, BioReagent, suitable for cell culture

Synonym: EGF, Epidermal cell growth factor



Related Categories Cancer Research, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines & Growth Factors,
Quality Level   200
biological source   mouse submaxillary glands
product line   BioReagent
assay   ≥98% (SDS-PAGE)
form   lyophilized powder
potency   0.02-2.0 ng/mL EC50
packaging   pkg of 0.1 mg
storage condition   avoid repeated freeze/thaw cycles
application(s)   cell culture | mammalian: suitable
impurities   endotoxin, tested
color   white
storage temp.   2-8°C
Gene Information   mouse ... Egf(13645)


General description

Epidermal growth factor (EGF) is the member of EGF-like family of growth factors, that binds to EGF receptor. It is majorly expressed in kidney, parotid gland and salivary gland.


Epidermal Growth Factor from murine submaxillary gland has been used
• in studying its effects on the development of caustic esophageal stricture in rats
• for preparation of MCF-10A cell line
• for the culture of primary hair follicle stem cells from arbas cashmere goat (gHFSCs) and adhesion of hair follicles (HF)

Biochem/physiol Actions

Epidermal growth factor (EGF) blocks gastric acid and pepsin secretion and increases gastrointestinal cell proliferation. EGF stimulates proliferation and migration in bone marrow stromal cells (BMSC), that gives rise to osteoblasts, chondrocytes and adipocytes. It functions as a strong mitogenic factor for various cultured cells. Mutations in this gene is linked to hypomagnesemia. EGF plays a major role in the maintenance of hair and skin development.

Physical form

Lyophilized from 0.2 μm filtered solution in ammonium acetate buffer.

Preparation Note

Purified by gel filtration and ion-exchange chromatography.

Analysis Note

The biological activity is measured in a proliferation assay using BALB/MK cells.

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles


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Keywords: Cell culture, DNA purification, Growth factors, High performance liquid chromatography, Polymerase chain reaction, Purification, Thin layer chromatography

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